PI16-CD26 interaction: A new mechanism for immune tolerance in humans?

Chief Investigator:

Dr Cheryl Brown

Funding Amount:



Women’s & Children’s Health Research Institute


Specialised cells called regulatory T cells, or Tregs, are the policemen of the immune system, and are essential for a balanced healthy immune response. However, in type 1 diabetes, there is a breakdown in function of Treg, leading to the onset of autoimmune disease. We have discovered a new molecule called PI16, and we are investigating a new mechanism by which PI16 regulates immune responses in healthy children, but which is altered in type 1 diabetes

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