Investigations into sepsis-induced high-mobility group box 1 (HMGB1) and effects on neurodevelopment in survivors of neonatal sepsis

Chief Investigator:

Dr Kerrilyn Diener

Funding Amount:



The University of Adelaide


Preterm babies are particularly vulnerable to acquiring sepsis during their hospital stay, which not only increases the risk of mortality, but also the likelihood of brain-related disorders in survivors from 28% to 49%. There is an emerging concept that HMGB1, a danger molecule released within the body as a result of sepsis, can perpetuate this abnormal brain development. We will investigate this further, as our aim is to develop a targeted therapy that will increase survival rates and support normal brain development. This will significantly benefit the long-term health for preterm neonates.

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