Chief Investigator: Associate Professor Cheryl Shoubridge

Funding Amount : $93,488

Recipient: The University of Adelaide

Overview: Developmental and epileptic encephalopathies (DEE) are a severe form of epilepsy which presents in early childhood. Affected children are treated with anti-epileptic drugs that often do not provide any relief from seizures, with ongoing seizures further impacting the development of the brain. These conditions are so rare individually that they are not of interest to drug companies. Here we propose using our clinically relevant genetic mouse model that recapitulates the seizure phenotype in patients to effectively screen and evaluate drug responses. These findings may guide clinicians to bring seizures under better, earlier control leading to better outcomes for patients.