Studies into the mechanisms that progress protracted bacterial bronchitis to bronchiectasis in children, and therapeutic targeting of these processes

Chief Investigator:

Professor Sandra Hodge

Funding Amount:



Hanson Institute


Inadequate diagnosis and treatment of recurrent Protracted Bacterial Bronchitis (PBB) may lead to reduced lung function and lower life-expectancy. We have found defective airway macrophage phagocytic function in these children that may contribute to a progression of PBB to bronchiectasis. We also found that the macrophage dysfunction in adults with chronic lung disease is associated with sphingosine signalling and that this system is a therapeutic target for FTY720 and macrolide antibiotics. Translating this data to the paediatric setting has a high likelihood of identifying new therapies.

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